Diamon Frank, Dharamraj Claude, Luther Stephen, Eichler Duane
Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA.
J Pediatr Endocrinol Metab. 2008 Dec;21(12):1133-8. doi: 10.1515/JPEM.2008.21.12.1133.
Rapid growth in infancy may be associated with later onset childhood obesity. The aim in this study was to evaluate the relationships of adipokines to growth of infants at 6-10 months of age and to serum insulin, glucose, and auxological parameters of infants and their mothers.
Thirty-seven healthy term AGA formula fed infants, 21 males, mean age 7.0 +/- 1.2 (SD) months, were evaluated during a nutritional assessment at a county health department. Length, weight, head circumference, waist circumference, mid-arm circumference, and subscapular skin fold and triceps skin fold thickness were determined. Mothers were weighed and their height measured, birth weight recorded from clinic records, and the infant's dietary history reviewed. Following finger stick for assessment of hemoglobin, a bedside blood glucose was determined and 250 microl of additional serum taken for assay of total adiponectin, high molecular weight (HMW) adiponectin (n=12), leptin, and insulin.
The infants' total adiponectin to leptin ratio correlated significantly with the change in body weight from birth to mid-infancy (r = 0.349, p < 0.05). The mean total adiponectin was 34.2 - 16.6 microg/ml (n=37), mean HMW adiponectin 12.2 +/- 9.0 microg/ml (n=12), mean HMW/total adiponectin ratio 34.3 +/- 17.6%, and mean leptin 1.3 +/- 1.2 ng/ml. Neither total nor HMW adiponectin, leptin, nor the leptin/adiponectin ratio, correlated with serum insulin, glucose/insulin ratio, hemoglobin, birth weight, or auxological determinations of the infants or mothers.
As leptin and adiponectin are both insulin sensitizing hormones that change inversely with acquisition of body fat, and the leptin/adiponectin ratio correlates significantly with weight gain in mid-infancy, we postulate that this ratio might provide a marker relating to infantile growth and later adiposity.
婴儿期快速生长可能与儿童期后期肥胖的发生有关。本研究的目的是评估脂肪因子与6至10个月龄婴儿生长以及婴儿及其母亲的血清胰岛素、血糖和体格学参数之间的关系。
在县卫生部门进行营养评估期间，对37名健康足月适于胎龄配方奶喂养的婴儿进行了评估，其中21名男性，平均年龄7.0±1.2（标准差）个月。测定了身长、体重、头围、腰围、上臂围、肩胛下皮褶厚度和肱三头肌皮褶厚度。对母亲进行称重并测量身高，从临床记录中记录出生体重，并回顾婴儿的饮食史。在进行手指采血评估血红蛋白后，测定床边血糖，并采集250微升额外血清用于检测总脂联素、高分子量（HMW）脂联素（n = 12）、瘦素和胰岛素。
婴儿的总脂联素与瘦素之比与出生至婴儿中期体重变化显著相关（r = 0.349，p < 0.05）。总脂联素平均为34.2 - 16.6微克/毫升（n = 37），HMW脂联素平均为12.2±9.0微克/毫升（n = 12），HMW/总脂联素平均比值为34.3±17.6%，瘦素平均为1.3±1.2纳克/毫升。总脂联素、HMW脂联素、瘦素或瘦素/脂联素比值均与婴儿或母亲的血清胰岛素、血糖/胰岛素比值、血红蛋白、出生体重或体格学测定值无关。
由于瘦素和脂联素都是胰岛素增敏激素，与体脂增加呈负相关，且瘦素/脂联素比值与婴儿中期体重增加显著相关，我们推测该比值可能是与婴儿生长及后期肥胖相关的一个标志物。
