Faculty of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Department of Cardiology, University Medical Center "Bežanijska Kosa", Dr Zoza Matea bb, 11080 Belgrade, Serbia.
Int J Mol Sci. 2023 Feb 13;24(4):3708. doi: 10.3390/ijms24043708.
Mesenchymal stem cells (MSCs) are adult stem cells that reside in almost all postnatal tissues where, due to the potent regenerative, pro-angiogenic and immunomodulatory properties, regulate tissue homeostasis. Obstructive sleep apnea (OSA) induces oxidative stress, inflammation and ischemia which recruit MSCs from their niches in inflamed and injured tissues. Through the activity of MSC-sourced anti-inflammatory and pro-angiogenic factors, MSCs reduce hypoxia, suppress inflammation, prevent fibrosis and enhance regeneration of damaged cells in OSA-injured tissues. The results obtained in large number of animal studies demonstrated therapeutic efficacy of MSCs in the attenuation of OSA-induced tissue injury and inflammation. Herewith, in this review article, we emphasized molecular mechanisms which are involved in MSC-based neo-vascularization and immunoregulation and we summarized current knowledge about MSC-dependent modulation of OSA-related pathologies.
间充质干细胞（MSCs）是存在于几乎所有出生后组织中的成体干细胞，由于其强大的再生、促血管生成和免疫调节特性，调节组织内稳态。阻塞性睡眠呼吸暂停（OSA）会引起氧化应激、炎症和缺血，从而从炎症和受损组织的龛位招募 MSCs。通过 MSC 来源的抗炎和促血管生成因子的活性，MSCs 减轻缺氧、抑制炎症、防止纤维化，并增强 OSA 损伤组织中受损细胞的再生。大量动物研究的结果表明，MSCs 在减轻 OSA 引起的组织损伤和炎症方面具有治疗效果。在此，在这篇综述文章中，我们强调了涉及基于 MSC 的新血管生成和免疫调节的分子机制，并总结了目前关于 MSC 依赖性调节 OSA 相关病理的知识。
