Zeiser Robert, Maas Kristina, Youssef Sawsan, Dürr Christoph, Steinman Lawrence, Negrin Robert S
Department of Haematology and Oncology, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Immunology. 2009 May;127(1):18-25. doi: 10.1111/j.1365-2567.2008.03011.x.
The 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) interfere with the mevalonate pathway. While initially developed for their lipid-lowering properties, statins have been extensively investigated with respect to their impact on autoantigen and alloantigen driven immune responses. Mechanistically it was shown that statins modify immune responses on several levels, including effects on dendritic cells, endothelial cells, macrophages, B cells and T cells. Several lines of evidence suggest that statins act in a disease-specific manner and are not effective in each immune disorder. This review discusses possible modes of action of statins in modulating immunity towards autoantigens and alloantigens.
3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂(他汀类药物)干扰甲羟戊酸途径。虽然他汀类药物最初是因其降脂特性而开发的,但人们已对其对自身抗原和同种异体抗原驱动的免疫反应的影响进行了广泛研究。从机制上看,已表明他汀类药物在多个层面上改变免疫反应,包括对树突状细胞、内皮细胞、巨噬细胞、B细胞和T细胞的影响。多项证据表明,他汀类药物以疾病特异性方式发挥作用,并非对每种免疫疾病都有效。本综述讨论了他汀类药物在调节针对自身抗原和同种异体抗原的免疫方面可能的作用方式。