Hasan AbdulAziz A, Ciancio Sebastian
Department of Preventive and Developmental Sciences, Kuwait University, Kuwait.
J Int Acad Periodontol. 2009 Jan;11(1):155-9.
To determine the relationship between aphthous-like ulcers and the ingestion of non-steroidal anti-inflammatory drugs.
A total of 150 subjects were included in this study. The study group consisted of 75 subjects who presented with clinical signs of aphthous-like ulcers. The control group consisted of 75 subjects with no clinical signs or history of oral ulcers. All subjects were clinically examined and received a questionnaire which included a history of non-steroidal anti-inflammatory drugs intake.
The results of this study demonstrated a possible relationship between aphthous-like ulcers and non-steroidal anti-inflammatory drugs intake. There was a statistically significant increase in the prevalence of the ulcers in subjects taking NSAIDs (p <0.0001).
Physicians and dentists may need to investigate the use of non-steroidal anti-inflammatory drugs with patients diagnosed with aphthous-like ulcers and may require them to reduce or stop the use of these medications or change them to other types of medications, especially when other contributing factors are eliminated.
确定类阿弗他溃疡与非甾体抗炎药摄入之间的关系。
本研究共纳入150名受试者。研究组由75名出现类阿弗他溃疡临床症状的受试者组成。对照组由75名无口腔溃疡临床症状或病史的受试者组成。所有受试者均接受临床检查并填写一份问卷，其中包括非甾体抗炎药摄入史。
本研究结果表明类阿弗他溃疡与非甾体抗炎药摄入之间可能存在关联。服用非甾体抗炎药的受试者溃疡患病率有统计学意义的增加（p<0.0001）。
医生和牙医可能需要对诊断为类阿弗他溃疡的患者调查其非甾体抗炎药的使用情况，可能需要他们减少或停用这些药物，或更换为其他类型的药物，尤其是在消除其他促成因素时。
