Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands.
Int J Clin Pract. 2009 Feb;63(2):233-42. doi: 10.1111/j.1742-1241.2008.01954.x.
Data on medication adverse effects (AEs) in chronic heart failure (CHF) are primarily based on results from clinical trials. Little is known about AEs perceived by CHF patients in daily practice and how patients deal with these subjective AEs.
To describe the scope and nature of perceived AEs of CHF patients, their coping strategies and the relationship of perceived AEs to medication, patient characteristics and quality of life.
This cross-sectional observational study included a sample of 680 patients previously hospitalised for CHF. Perceived AEs and coping strategies were collected by interviews based on a structured questionnaire. Medication and clinical information were collected by chart review.
Of the 670 CHF patients completing the questionnaire, 17% reported at least one AE. In total, 186 AEs were reported of which 15% could not be linked to any medication. Nausea (4%), dizziness (4%), itches (3%) and rash (3%) were the most prevalent. The drug associated with the highest AE rate was pravastatin (27%). On average, more than five different drugs could be related to the AEs headache, dizziness and nausea. Patients reporting AEs had a lower general health perception, younger age and were more often using antiarrhythmic drugs. Of patients experiencing AEs, 69% conferred with their doctor, 24% reported having done nothing in reaction and 2% discontinued their medication without discussing it with the doctor.
Adverse effects are frequently perceived by CHF patients, but they are difficult to recognise and manage in daily practice.
药物不良反应（AE）的数据主要基于临床试验的结果。在日常实践中，关于慢性心力衰竭（CHF）患者感知到的 AE 知之甚少，也不清楚患者如何应对这些主观 AE。
描述 CHF 患者感知到的 AE 的范围和性质、他们的应对策略，以及感知到的 AE 与药物、患者特征和生活质量的关系。
本横断面观察性研究纳入了 680 例先前因 CHF 住院的患者。通过基于结构化问卷的访谈收集感知到的 AE 和应对策略。通过病历回顾收集药物和临床信息。
在完成问卷的 670 例 CHF 患者中，17%报告至少有一种 AE。共报告了 186 种 AE，其中 15%无法与任何药物相关联。最常见的是恶心（4%）、头晕（4%）、瘙痒（3%）和皮疹（3%）。与 AE 发生率最高相关的药物是普伐他汀（27%）。平均而言，超过五种不同的药物可能与头痛、头晕和恶心的 AE 有关。报告 AE 的患者总体健康状况较差，年龄较小，更常使用抗心律失常药物。在经历 AE 的患者中，69%与医生讨论过，24%报告没有采取任何措施，2%在没有与医生讨论的情况下停止了用药。
AE 经常被 CHF 患者感知到，但在日常实践中很难识别和管理。
