Carabin Ioana G, Lyon Michael R, Wood Simon, Pelletier Xavier, Donazzolo Yves, Burdock George A
Burdock Group, Orlando, Florida, USA.
Nutr J. 2009 Feb 5;8:9. doi: 10.1186/1475-2891-8-9.
The relationship of dietary fiber to overall health is of great importance, as beneficial effects have been demonstrated with the use of fiber from diverse sources, some traditional, other novel. PolyGlycopleX (PGX) is a unique proprietary product composed of three water-soluble polysaccharides, that when processed using novel technology give rise to a final product - a soluble, highly viscous functional fiber.
Because of its potential use in food and dietary supplements, a randomized, double-blind, placebo controlled clinical study was conducted to evaluate the tolerance to PGX ingestion for 21 days, to a maximum dose level of 10 g per day, in healthy male and female volunteers. The main objective of the study was to evaluate the overall gastrointestinal (GI) tolerance, while secondary objectives were to evaluate possible changes in hematological, biochemical, urinary and fecal parameters.
Results show that PGX is well tolerated as part of a regular diet with only mild to moderate adverse effects, similar to those seen with a moderate intake of dietary fiber in general, and fruits and vegetables. Because PGX is a highly viscous, functional fiber, it also demonstrates several physiological responses including, but not limited to maintaining healthy total and LDL cholesterol and uric acid levels.
膳食纤维与整体健康的关系至关重要，因为已证明来自不同来源（一些是传统来源，另一些是新型来源）的纤维具有有益作用。聚葡萄糖复合纤维（PGX）是一种独特的专利产品，由三种水溶性多糖组成，采用新技术加工后会形成最终产品——一种可溶性、高粘性的功能性纤维。
由于其在食品和膳食补充剂中的潜在用途，对健康男性和女性志愿者进行了一项随机、双盲、安慰剂对照的临床研究，以评估连续21天摄入PGX至每日最大剂量10克的耐受性。该研究的主要目的是评估总体胃肠道（GI）耐受性，次要目的是评估血液学、生化、尿液和粪便参数的可能变化。
结果表明，PGX作为常规饮食的一部分耐受性良好，仅产生轻度至中度不良反应，与一般中等摄入量的膳食纤维以及水果和蔬菜产生的不良反应相似。由于PGX是一种高粘性的功能性纤维，它还表现出多种生理反应，包括但不限于维持健康的总胆固醇和低密度脂蛋白胆固醇水平以及尿酸水平。
