2型糖尿病成人患者中的肥胖与蛋白尿：“展望”（糖尿病健康行动）研究
Obesity and albuminuria among adults with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) Study.
作者信息
Kramer Holly, Reboussin David, Bertoni Alain G, Marcovina Santica, Lipkin Edward, Greenway Frank L, Brancati Frederick L
机构信息
Department of Preventive Medicine and Epidemiology, Division of Nephrology and Hypertension, Loyola University Medical Center, Maywood, Illinois, USA.
出版信息
Diabetes Care. 2009 May;32(5):851-3. doi: 10.2337/dc08-2059. Epub 2009 Feb 5.
Abstract
OBJECTIVE
To determine the association between obesity measures and albuminuria in adults with type 2 diabetes.
RESEARCH DESIGN AND METHODS
In the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent total body fat were calculated using logistic regression analysis while adjusting for covariates.
RESULTS
The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40-2.11]) and waist circumference (OR 1.75 [95% CI 1.42-2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in any model.
CONCLUSIONS
Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.
摘要
目的
确定2型糖尿病成年患者肥胖指标与蛋白尿之间的关联。
研究设计与方法
在“糖尿病健康行动”（Look AHEAD）研究中，对4985名参与者测量了体重指数（BMI）和腰围，对1351名参与者通过全身双能X线吸收法扫描测量了全身脂肪百分比。使用逻辑回归分析计算BMI、腰围和全身脂肪百分比四分位数对应的蛋白尿比值比，并对协变量进行校正。
结果
校正协变量后，BMI最高四分位数（比值比[OR]为1.72[95%置信区间为1.40 - 2.11]）和腰围最高四分位数（OR为1.75[95%置信区间为1.42 - 2.15]）与最低四分位数相比，与蛋白尿显著相关。在任何模型中，全身脂肪百分比四分位数与蛋白尿之间均未发现关联。
结论
在超重和肥胖的2型糖尿病成年患者中，BMI升高和腹型肥胖与蛋白尿相关。
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