精神分裂症中的抑郁：方法学假象还是该疾病的独特特征？
Depression in schizophrenia: methodological artifact or distinct feature of the illness?
作者信息
Chemerinski Eran, Bowie Christopher, Anderson Hannah, Harvey Philip D
机构信息
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2008 Fall;20(4):431-40. doi: 10.1176/jnp.2008.20.4.431.
Abstract
In schizophrenia, there is a conceptual overlap between depressive and negative symptoms. This study examined the dimensional structure of depressive symptoms and their overlap with negative symptoms in a large sample of older medicated schizophrenia outpatients. Self-reported depression was obtained with the Beck Depression Inventory-II (BDI-II). Three components from this scale (i.e., dysphoria, psychosomatic and regret domains) showed excellent factorability and good consistency. However, adequate construct validity and correlates with outcomes were found for the dysphoria and regret domains, but not for the total score or the psychosomatic domain. Thus, the evaluation of domains within the BDI-II provides a more pure and clinically-relevant assessment of depressed mood in schizophrenia than the use of this scale as a whole.
摘要
在精神分裂症中，抑郁症状和阴性症状之间存在概念上的重叠。本研究在大量老年药物治疗的精神分裂症门诊患者样本中，考察了抑郁症状的维度结构及其与阴性症状的重叠情况。使用贝克抑郁量表第二版（BDI-II）获取自我报告的抑郁情况。该量表的三个分量表（即烦躁不安、身心症状和后悔领域）显示出良好的因子可分解性和一致性。然而，烦躁不安和后悔领域具有足够的结构效度并与结果相关，而总分或身心症状领域则不然。因此，与整体使用该量表相比，对BDI-II内各领域的评估能更纯粹且与临床相关地评估精神分裂症患者的抑郁情绪。
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