Wozniak Michele A, Chen Christopher S
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Nat Rev Mol Cell Biol. 2009 Jan;10(1):34-43. doi: 10.1038/nrm2592.
Mechanotransduction research has focused historically on how externally applied forces can affect cell signalling and function. A growing body of evidence suggests that contractile forces that are generated internally by the actomyosin cytoskeleton are also important in regulating cell behaviour, and suggest a broader role for mechanotransduction in biology. Although the molecular basis for these cellular forces in mechanotransduction is being pursued in cell culture, researchers are also beginning to appreciate their contribution to in vivo developmental processes. Here, we examine the role for mechanical forces and contractility in regulating cell and tissue structure and function during development.
从历史上看，机械转导研究一直聚焦于外部施加的力如何影响细胞信号传导和功能。越来越多的证据表明，由肌动球蛋白细胞骨架内部产生的收缩力在调节细胞行为方面也很重要，这表明机械转导在生物学中具有更广泛的作用。尽管细胞培养中正在探索这些细胞力在机械转导中的分子基础，但研究人员也开始认识到它们对体内发育过程的贡献。在这里，我们研究了机械力和收缩性在发育过程中调节细胞和组织结构及功能方面的作用。
