• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1.通过人ITPK1整合肌醇磷酸信号通路的分子基础。
Adv Enzyme Regul. 2009;49(1):87-96. doi: 10.1016/j.advenzreg.2008.12.008. Epub 2009 Jan 3.
2
Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels.人ITPK1：一种可逆的肌醇磷酸激酶/磷酸酶，它将受体依赖性磷脂酶C与Ca2+激活的氯离子通道联系起来。
Sci Signal. 2008 Jan 29;1(4):pe5. doi: 10.1126/stke.14pe5.
3
Integration of inositol phosphate signaling pathways via human ITPK1.通过人肌醇多磷酸激酶1整合肌醇磷酸信号通路。
J Biol Chem. 2007 Sep 21;282(38):28117-25. doi: 10.1074/jbc.M703121200. Epub 2007 Jul 6.
4
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes.肌醇磷酸酯和肌醇焦磷酸酯在发育、细胞信号传导及核过程中的作用。
Adv Enzyme Regul. 2010;50(1):324-37. doi: 10.1016/j.advenzreg.2009.12.002. Epub 2009 Dec 16.
5
Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects.肌醇1,3,4-三磷酸5/6激酶（ITPK1）的表达及其在神经管缺陷中的作用。
Adv Enzyme Regul. 2010;50(1):365-72. doi: 10.1016/j.advenzreg.2009.10.017. Epub 2009 Nov 13.
6
ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism.ITPK1 介导由代谢控制的不依赖于脂质的肌醇磷酸盐的合成。
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24551-24561. doi: 10.1073/pnas.1911431116. Epub 2019 Nov 21.
7
Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.果蝇 S3 细胞中内源性细胞因子 (GBP)对 PLC 的激活及其作为研究通过 ITPK1 进行肌醇磷酸信号转导的模型的应用。
Biochem J. 2012 Dec 1;448(2):273-83. doi: 10.1042/BJ20120730.
8
Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors.肌醇四磷酸1激酶抑制剂的生化与生物物理特性
J Biol Chem. 2025 Mar;301(3):108274. doi: 10.1016/j.jbc.2025.108274. Epub 2025 Feb 6.
9
ITPK1 is an InsP/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.ITPK1 是一种 InsP/ADP 磷酸转移酶，它控制着拟南芥中的磷酸信号转导。
Mol Plant. 2021 Nov 1;14(11):1864-1880. doi: 10.1016/j.molp.2021.07.011. Epub 2021 Jul 15.
10
Zebrafish inositol polyphosphate kinases: new effectors of cilia and developmental signaling.斑马鱼肌醇多磷酸激酶：纤毛和发育信号传导的新效应器
Adv Enzyme Regul. 2010;50(1):309-23. doi: 10.1016/j.advenzreg.2009.10.018. Epub 2009 Nov 13.

引用本文的文献

1
Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors.肌醇四磷酸1激酶抑制剂的生化与生物物理特性
J Biol Chem. 2025 Mar;301(3):108274. doi: 10.1016/j.jbc.2025.108274. Epub 2025 Feb 6.
2
Necroptosis-Related Gene Signature Predicts Prognosis in Patients with Advanced Ovarian Cancer.坏死性凋亡相关基因特征预测晚期卵巢癌患者的预后
Cancers (Basel). 2025 Jan 15;17(2):271. doi: 10.3390/cancers17020271.
3
The Inositol Phosphate System-A Coordinator of Metabolic Adaptability.肌醇磷酸系统——代谢适应性的协调者。
Int J Mol Sci. 2022 Jun 16;23(12):6747. doi: 10.3390/ijms23126747.
4
Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles.灵长类慢病毒的生产需要肌醇六磷酸（IP6）或肌醇五磷酸（IP5）。
PLoS Pathog. 2020 Aug 10;16(8):e1008646. doi: 10.1371/journal.ppat.1008646. eCollection 2020 Aug.
5
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.MLKL 需要肌醇磷酸盐码来执行细胞坏死性凋亡。
Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010.
6
SnapShot: Inositol phosphates.简要概述：肌醇磷酸酯
Cell. 2010 Dec 10;143(6):1030-1030.e1. doi: 10.1016/j.cell.2010.11.045.
7
Lipid signaling in T-cell development and function.T 细胞发育和功能中的脂质信号转导。
Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a002428. doi: 10.1101/cshperspect.a002428. Epub 2010 Oct 13.
8
Serine protease activities in Leishmania (Leishmania) chagasi promastigotes.巴西利什曼原虫（Leishmania）鞭毛体中的丝氨酸蛋白酶活性。
Parasitol Res. 2010 Oct;107(5):1151-62. doi: 10.1007/s00436-010-1983-y. Epub 2010 Jul 29.
9
Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate.通过可溶肌醇 1,3,4,5-四磷酸调节免疫细胞的发育。
Nat Rev Immunol. 2010 Apr;10(4):257-71. doi: 10.1038/nri2745.
10
Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling.三磷酸肌醇 3-激酶：聚焦免疫和神经元信号转导。
Cell Mol Life Sci. 2010 Jun;67(11):1755-78. doi: 10.1007/s00018-009-0238-5. Epub 2010 Jan 12.

本文引用的文献

1
An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function.通过对ClC-3功能的调节，肌醇(3,4,5,6)四磷酸具有扩展的生物学功能谱。
Curr Biol. 2008 Oct 28;18(20):1600-5. doi: 10.1016/j.cub.2008.08.073.
2
The ClC-0 chloride channel is a 'broken' Cl-/H+ antiporter.氯离子通道ClC-0是一种“失活的”氯离子/氢离子反向转运体。
Nat Struct Mol Biol. 2008 Aug;15(8):805-10. doi: 10.1038/nsmb.1466. Epub 2008 Jul 20.
3
The role of inositol signaling in the control of apoptosis.肌醇信号在细胞凋亡调控中的作用。
Adv Enzyme Regul. 2008;48:10-7. doi: 10.1016/j.advenzreg.2008.04.001. Epub 2008 Apr 29.
4
Metabolic and signaling properties of an Itpk gene family in Glycine max.大豆中一个肌醇多磷酸激酶（Itpk）基因家族的代谢和信号传导特性
FEBS Lett. 2008 Jun 11;582(13):1853-8. doi: 10.1016/j.febslet.2008.04.054. Epub 2008 May 12.
5
Suppression of ClC-3 channel expression reduces migration of nasopharyngeal carcinoma cells.ClC-3通道表达的抑制减少了鼻咽癌细胞的迁移。
Biochem Pharmacol. 2008 May 1;75(9):1706-16. doi: 10.1016/j.bcp.2008.01.008. Epub 2008 Feb 5.
6
Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells.血小板活化因子诱导的氯离子通道激活与肠上皮细胞的细胞内酸中毒和凋亡有关。
Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1191-200. doi: 10.1152/ajpgi.00318.2007. Epub 2008 Mar 13.
7
CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.CLC氯离子通道与转运体：从基因到蛋白质结构、病理学与生理学
Crit Rev Biochem Mol Biol. 2008 Jan-Feb;43(1):3-36. doi: 10.1080/10409230701829110.
8
Intracellular ClC-3 chloride channels promote bone resorption in vitro through organelle acidification in mouse osteoclasts.细胞内的氯离子通道ClC-3通过使小鼠破骨细胞内细胞器酸化来促进体外骨吸收。
Am J Physiol Cell Physiol. 2008 Mar;294(3):C693-701. doi: 10.1152/ajpcell.00251.2007. Epub 2008 Jan 30.
9
Expression pattern of inositol phosphate-related enzymes in rice (Oryza sativa L.): implications for the phytic acid biosynthetic pathway.水稻（Oryza sativa L.）中肌醇磷酸相关酶的表达模式：对植酸生物合成途径的影响。
Gene. 2007 Dec 15;405(1-2):55-64. doi: 10.1016/j.gene.2007.09.006. Epub 2007 Sep 14.
10
Inositol polyphosphates: a new frontier for regulating gene expression.肌醇多磷酸：调控基因表达的新前沿。
Chromosoma. 2008 Feb;117(1):1-13. doi: 10.1007/s00412-007-0126-4. Epub 2007 Oct 18.

Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1.

作者信息

Shears Stephen B

机构信息

Inositol Signaling Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, USA.

出版信息

Adv Enzyme Regul. 2009;49(1):87-96. doi: 10.1016/j.advenzreg.2008.12.008. Epub 2009 Jan 3.

DOI:10.1016/j.advenzreg.2008.12.008
PMID:19200440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4770455/
Abstract
摘要