Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
Nat Rev Immunol. 2010 Apr;10(4):257-71. doi: 10.1038/nri2745.
The membrane lipid phosphatidylinositol-3,4,5-trisphosphate (PtdInsP(3)) regulates membrane receptor signalling in many cells, including immunoreceptor signalling. Here, we review recent data that have indicated essential roles for the soluble PtdInsP(3) analogue inositol-1,3,4,5-tetrakisphosphate (InsP(4)) in T cell, B cell and neutrophil development and function. Decreased InsP(4) production in leukocytes causes immunodeficiency in mice and might contribute to inflammatory vasculitis in Kawasaki disease in humans. InsP(4)-producing kinases could therefore provide attractive drug targets for inflammatory and infectious diseases.
细胞膜脂质磷脂酰肌醇-3,4,5-三磷酸（PtdInsP(3)）调节许多细胞中的膜受体信号转导，包括免疫受体信号转导。在这里，我们回顾了最近的数据，这些数据表明可溶性 PtdInsP(3)类似物肌醇 1,3,4,5-四磷酸（InsP(4))在 T 细胞、B 细胞和中性粒细胞发育和功能中的重要作用。白细胞中 InsP(4)产量的降低会导致小鼠免疫缺陷，并且可能导致人类川崎病中的炎症性血管炎。因此，InsP(4)产生激酶可能成为炎症和感染性疾病有吸引力的药物靶点。
