Jihen El Heni, Imed Messaoudi, Fatima Hammouda, Abdelhamid Kerkeni
Département de Biophysique, Faculté de Médecine de Monastir, Unité de Recherche, Eléments Traces, Radicaux Libres, Antioxydants, Pathologies Humaines et Environnement, Tunisie.
Ecotoxicol Environ Saf. 2009 Jul;72(5):1559-64. doi: 10.1016/j.ecoenv.2008.12.006. Epub 2009 Feb 6.
Cadmium (Cd) is a very harmful environmental pollutant that transfers between various levels of the food chain. To study the protective effect of Se and Zn on Cd-induced oxidative stress in livers, male rats received either, tap water, Cd, Cd+Zn, Cd+Se or Cd+Zn+Se in their drinking water, for 35 days. The activities of total superoxide dismutase (SOD), copper, zinc-superoxide dismutase (CuZn SOD), glutathione peroxidase (GPx) and catalase (CAT), malondialdehyde (MDA) level and the ratio of CuZn SOD to GPx activity, were determined in the liver. Exposure to Cd lowered total SOD, CuZn SOD, GPx and CAT activities, while it increased MDA level and the ratio of CuZn SOD to GPx activity, in the organ studied. With Se or Zn administration during exposure to Cd, only partial corrective effects on Cd-induced oxidative stress in the liver have been observed, while Se and Zn together assured a more efficient protection of the organ against the observed oxidative stress.
镉（Cd）是一种极具危害性的环境污染物，可在食物链的各个层级间转移。为研究硒（Se）和锌（Zn）对镉诱导的肝脏氧化应激的保护作用，雄性大鼠在35天内饮用的自来水中分别添加了自来水、镉、镉+锌、镉+硒或镉+锌+硒。测定了肝脏中总超氧化物歧化酶（SOD）、铜锌超氧化物歧化酶（CuZn SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）的活性、丙二醛（MDA）水平以及CuZn SOD与GPx活性的比值。在所研究的器官中，接触镉会降低总SOD、CuZn SOD、GPx和CAT的活性，同时会提高MDA水平以及CuZn SOD与GPx活性的比值。在接触镉期间给予硒或锌，仅观察到对镉诱导的肝脏氧化应激有部分纠正作用，而硒和锌共同作用能更有效地保护该器官免受所观察到的氧化应激影响。
