Draelos Zoe Diana
Dermatology Consulting Services, High Point, North Carolina, USA.
Cutis. 2008 Nov;82(5 Suppl):17-20.
Treatment success in acne depends on appropriate selection of medication and vehicle for efficacy, tolerability, and convenience. Patient education provided by the clinician also is important to ensure optimum compliance. Involving the patient in medication and daily skin care selections also increases the likelihood of compliance. Most patients will be using some combination of a topical retinoid with benzoyl peroxide (BPO) and a topical or oral antibiotic. Benzoyl peroxide and topical retinoids can alter skin barrier integrity. Selection of a moisturizing vehicle is important to repair the skin barrier and improve tolerability. A fixed clindamycin 1%-BPO 5% (C/BPO) combination in a moisturizing gel base has a favorable tolerability profile and patient preference.
痤疮治疗的成功取决于为实现疗效、耐受性和便利性而对药物及剂型的恰当选择。临床医生提供的患者教育对于确保最佳依从性也很重要。让患者参与药物及日常皮肤护理的选择也会增加依从的可能性。大多数患者会联合使用某种外用维甲酸与过氧化苯甲酰（BPO）以及外用或口服抗生素。过氧化苯甲酰和外用维甲酸会改变皮肤屏障的完整性。选择一种保湿剂型对于修复皮肤屏障和提高耐受性很重要。一种含1%克林霉素-5%BPO（C/BPO）的固定组合保湿凝胶剂型具有良好的耐受性和患者偏好性。
