Kim Myung-Sun, Jang Kyoung-Mi, Kim Bit-Na
Department of Psychology, Sungshin Women's University, Seoul, Korea.
J Int Neuropsychol Soc. 2009 Mar;15(2):286-90. doi: 10.1017/S1355617709090213. Epub 2009 Feb 10.
We investigated the neuropsychological profile of subjects in a subclinical obsessive-compulsive disorder (OCD) sample. Psychometrically defined subclinical obsessive-compulsive (n = 21) and control (n = 22) subjects were examined. Comprehensive neuropsychological tests evaluating verbal/nonverbal memory, attention, and executive function were administered. The subclinical obsessive-compulsive group showed poorer performances on the Wisconsin Card Sorting Test (WCST), F(1, 41) = 13.80, p < .001, and Trail-Making Test (TMT), F(1, 41) = 5.48, p < .05, compared with the control group. The subclinical obsessive-compulsive group showed higher rates of total errors, perseverative errors, and perseverative responses. In addition, the subclinical obsessive-compulsive group committed a greater number of errors in the TMT. However, the groups showed no performance differences in the TMT after controlling for the effects of depression and anxiety, F(1, 39) = 0.11, p = .739. These results suggest that subclinical obsessive-compulsives seemed to display deficits in executive functioning. This neuropsychological profile is consistent with current theories proposing that executive dysfunction may serve as the pathophysiological mechanism underlying the development of obsessive-compulsive disorder.
我们研究了亚临床强迫症（OCD）样本中受试者的神经心理学特征。对通过心理测量学定义的亚临床强迫症状组（n = 21）和对照组（n = 22）的受试者进行了检查。实施了评估言语/非言语记忆、注意力和执行功能的全面神经心理学测试。与对照组相比，亚临床强迫症状组在威斯康星卡片分类测试（WCST）中表现较差，F(1, 41) = 13.80，p <.001；在连线测验（TMT）中表现也较差，F(1, 41) = 5.48，p <.05。亚临床强迫症状组的总错误率、持续性错误率和持续性反应率更高。此外，亚临床强迫症状组在TMT中犯的错误更多。然而，在控制抑郁和焦虑的影响后，两组在TMT中的表现没有差异，F(1, 39) = 0.11，p =.739。这些结果表明，亚临床强迫症状者似乎在执行功能方面存在缺陷。这种神经心理学特征与当前的理论一致，该理论提出执行功能障碍可能是强迫症发展的病理生理机制。
