氨基酸重排激活mTORC1。
An amino acid shuffle activates mTORC1.
作者信息
Cohen Adiel, Hall Michael N
机构信息
Biozentrum, University of Basel, Basel, Switzerland.
出版信息
Cell. 2009 Feb 6;136(3):399-400. doi: 10.1016/j.cell.2009.01.021.
PMID:19203575
Abstract
The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.
摘要
促进细胞生长的雷帕霉素复合物1（mTORC1）的哺乳动物靶点受特定营养素（如氨基酸亮氨酸）的调节。在本期中，尼克林等人（2009年）描述了一种机制，通过该机制谷氨酰胺促进亮氨酸的摄取，从而导致mTORC1激活。
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