Pirofski Liise-anne, Casadevall Arturo
Department of Medicine, Albert Einstein College of Medicine College of Medicine, Bronx, NY, USA.
J Exp Med. 2009 Feb 16;206(2):269-73. doi: 10.1084/jem.20090093. Epub 2009 Feb 9.
The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.
在女性艾滋病患者中,口咽念珠菌病(OPC)相较于系统性念珠菌病和阴道念珠菌病出现了不成比例的增加,这一现象近三十年来一直是个悖论。新数据表明,严重OPC在缺乏Th17的小鼠中会发生,但在缺乏Th1的小鼠中不会,这表明Th17诱导的效应分子在抵抗口腔疾病中发挥作用。这些发现阐明并拓展了我们目前对于CD4 T细胞缺乏如何影响OPC易感性的认识。