高效抗逆转录病毒治疗（HAART）开始后皮肤真菌病发病率增加：一种免疫重建疾病的良性形式？

Increased incidence of cutaneous mycoses after HAART initiation: a benign form of immune reconstitution disease?

作者信息

Nacher Mathieu, Vantilcke Vincent, Mahamat Aba, El Guedj Myriam, Vaz Tania, Randrianjohany Andry, Clyti Emmanuel, Aznar Christine, Carme Bernard, Couppié Pierre

机构信息

COREVIH Cayenne General Hospital, 97300 Cayenne, French Guiana.

出版信息

AIDS. 2007 Oct 18;21(16):2248-50. doi: 10.1097/QAD.0b013e3282887ea7.

DOI:10.1097/QAD.0b013e3282887ea7

PMID:18090055

Abstract

Immune reconstitution disease (IRD) has been associated with many pathogens after the initiation of antiretroviral therapy for advanced HIV infection. A retrospective cohort study was conducted to determine whether cutaneous mycoses were also associated with IRD. After adjusting for various confounding factors, the recent initiation of HAART was found to be associated with an increased incidence of cutaneous mycoses when compared with untreated patients.

摘要

免疫重建疾病（IRD）在晚期HIV感染患者开始抗逆转录病毒治疗后与多种病原体相关。进行了一项回顾性队列研究，以确定皮肤真菌病是否也与IRD相关。在调整各种混杂因素后，发现与未治疗的患者相比，近期开始高效抗逆转录病毒治疗（HAART）与皮肤真菌病发病率增加有关。