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2
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3
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6
HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control.在急性和慢性进行性 HIV 感染中会诱导产生 HIV 特异性产生 IL-21 的 CD4+T 细胞，并且与相对病毒控制相关。
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Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases.靶向Th17细胞：治疗口腔黏膜炎症性疾病的一种有前景的策略。
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Murine cytomegalovirus promotes renal allograft inflammation via Th1/17 cells and IL-17A.鼠巨细胞病毒通过 Th1/17 细胞和白细胞介素-17A 促进肾移植炎症。
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本文引用的文献

1
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.白细胞介素1β和6而非转化生长因子β对于产生白细胞介素17的人辅助性T细胞的分化至关重要。
Nat Immunol. 2007 Sep;8(9):942-9. doi: 10.1038/ni1496. Epub 2007 Aug 5.
2
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.产生白细胞介素-17的人类辅助性T记忆细胞的表面表型和抗原特异性
Nat Immunol. 2007 Jun;8(6):639-46. doi: 10.1038/ni1467. Epub 2007 May 7.
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Differentiation and function of Th17 T cells.辅助性T细胞17（Th17）的分化与功能
Curr Opin Immunol. 2007 Jun;19(3):281-6. doi: 10.1016/j.coi.2007.04.005. Epub 2007 Apr 12.
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Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection.在人类免疫缺陷病毒感染中，辅助性T细胞亚群Th17和CD4阴性T细胞中白细胞介素-17的产生均增加。
Viral Immunol. 2007 Spring;20(1):66-75. doi: 10.1089/vim.2006.0063.
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T(H)-17 cells in the circle of immunity and autoimmunity.免疫与自身免疫循环中的辅助性T细胞17（Th17细胞）
Nat Immunol. 2007 Apr;8(4):345-50. doi: 10.1038/ni0407-345.
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A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.辅助性T细胞17简史，这是T细胞介导的组织损伤的辅助性T细胞1/辅助性T细胞2假说的首次重大修订。
Nat Med. 2007 Feb;13(2):139-45. doi: 10.1038/nm1551.
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection.微生物易位是慢性HIV感染中全身免疫激活的一个原因。
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8
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.孤儿核受体RORγt指导促炎性白细胞介素-17+辅助性T细胞的分化程序。
Cell. 2006 Sep 22;126(6):1121-33. doi: 10.1016/j.cell.2006.07.035.
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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.抗白细胞介素-23疗法可抑制多种炎症途径并改善自身免疫性脑脊髓炎。
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10
Transforming growth factor-beta induces development of the T(H)17 lineage.转化生长因子-β诱导辅助性T细胞17亚群的发育。
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在人类免疫缺陷病毒1型早期感染中可检测到产生病毒特异性白细胞介素-17的CD4+ T细胞。

Virus-specific interleukin-17-producing CD4+ T cells are detectable in early human immunodeficiency virus type 1 infection.

作者信息

Yue Feng Yun, Merchant Asad, Kovacs Colin M, Loutfy Mona, Persad Desmond, Ostrowski Mario A

机构信息

University of Toronto, Clinical Sciences Division, Toronto, ON, Canada M5S 1A8.

出版信息

J Virol. 2008 Jul;82(13):6767-71. doi: 10.1128/JVI.02550-07. Epub 2008 Apr 23.

DOI:10.1128/JVI.02550-07
PMID:18434403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2447083/
Abstract

T(H)-17 cells have been shown to play a role in bacterial defense, acute inflammation, and autoimmunity. We examined the role of interleukin 17 (IL-17) production in human immunodeficiency virus type 1 (HIV-1) infection. Both HIV-1- and cytomegalovirus (CMV)-specific IL-17-producing CD4(+) T cells were detectable in early HIV-1 infection but were reduced to nondetectable levels in chronic and nonprogressive HIV-1 infection. IL-17-producing CMV-specific cells were not detected in blood from HIV-1-uninfected normal volunteers. Virus-specific T(H)-17 cells could coexpress other cytokines and could express CCR4 or CXCR3. Although the etiology of these cells has yet to be established, we propose that microbial translocation may induce them.

摘要

辅助性T细胞17（T(H)-17细胞）已被证明在细菌防御、急性炎症和自身免疫中发挥作用。我们研究了白细胞介素17（IL-17）产生在1型人类免疫缺陷病毒（HIV-1）感染中的作用。在HIV-1感染早期可检测到HIV-1特异性和巨细胞病毒（CMV）特异性产生IL-17的CD4(+) T细胞，但在慢性和非进展性HIV-1感染中减少到检测不到的水平。在未感染HIV-1的正常志愿者血液中未检测到产生IL-17的CMV特异性细胞。病毒特异性T(H)-17细胞可共表达其他细胞因子，并可表达CCR4或CXCR3。尽管这些细胞的病因尚未明确，但我们认为微生物易位可能会诱导它们产生。