Tae Hongseok, Sohng Jae Kyung, Park Kiejung
SmallSoft Co, Ltd, Jang-Dong 59-5, Yusung-Gu, Daejeon 305-343, South Korea.
Bioprocess Biosyst Eng. 2009 Oct;32(6):723-7. doi: 10.1007/s00449-008-0296-3. Epub 2009 Feb 11.
Polyketides have diverse biological activities, including pharmacological functions such as antibiotic, antitumor and agrochemical properties. They are biosynthesized from short carboxylic acid precursors by polyketide synthases (PKSs). As natural polyketide products include many clinically important drugs and the volume of data on polyketides is rapidly increasing, the development of a database system to manage polyketide data is essential. MapsiDB is an integrated web database formulated to contain data on type I polyketides and their PKSs, including domain and module composition and related genome information. Data on polyketides were collected from journals and online resources and processed with analysis programs. Web interfaces were utilized to construct and to access this database, allowing polyketide researchers to add their data to this database and to use it easily.
聚酮化合物具有多种生物活性，包括抗生素、抗肿瘤和农用化学品等药理功能。它们由聚酮合酶（PKSs）从短链羧酸前体生物合成。由于天然聚酮化合物产品包括许多临床上重要的药物，并且关于聚酮化合物的数据量正在迅速增加，因此开发一个数据库系统来管理聚酮化合物数据至关重要。MapsiDB是一个集成的网络数据库，其构建目的是包含关于I型聚酮化合物及其聚酮合酶的数据，包括结构域和模块组成以及相关的基因组信息。聚酮化合物的数据是从期刊和在线资源中收集的，并使用分析程序进行处理。利用网络界面来构建和访问这个数据库，使聚酮化合物研究人员能够将他们的数据添加到这个数据库并轻松使用它。
