Timon C I, McShane D, Hamilton D, Walsh M A
Department of Otolaryngology, Toronto General Hospital, Ontario.
J Otolaryngol. 1991 Aug;20(4):283-7.
Antibodies reacting with cancer cells are playing an increasing role in cancer detection. Most antibodies under study are directed at onco-fetal proteins, principally carcino-embryonic antigen (CEA). In terms of imaging, most work has concentrated on the abdominal and pelvic regions. Although the majority of primary head and neck cancers are amiable to clinical identification, detection of regional metastases and recurrences following radiotherapy can be difficult. Antibody to CEA was radiolabelled with Indium-111 and used to identify proven head and neck tumors by external imaging. In seven patients with squamous cell tumors, five of five primary sites and two of three secondary sites were imaged satisfactory. Comparison with conventional scanning showed good correlation. There were no false positive scans, no consistent relationship between serum or tissue CEA levels and the success of imaging was evident. The success of this pilot study should encourage the search for more tumor-specific antigens, and further studies of external scintigraphic techniques in the localization of head and neck cancers.
与癌细胞发生反应的抗体在癌症检测中发挥着越来越重要的作用。目前大多数正在研究的抗体都针对癌胚蛋白，主要是癌胚抗原（CEA）。在成像方面，大多数研究都集中在腹部和盆腔区域。虽然大多数原发性头颈癌易于通过临床检查识别，但放疗后区域转移和复发的检测可能会很困难。用铟 - 111对癌胚抗原抗体进行放射性标记，并通过外部成像来识别已确诊的头颈肿瘤。在7例鳞状细胞瘤患者中，5个原发部位中的5个以及3个继发部位中的2个成像效果令人满意。与传统扫描结果相比显示出良好的相关性。没有出现假阳性扫描结果，血清或组织癌胚抗原水平与成像成功与否之间没有明显的一致性关系。这项初步研究的成功应该会促使人们寻找更多肿瘤特异性抗原，并进一步研究外部闪烁扫描技术在头颈癌定位中的应用。
