Schulze-Späte Ulrike, Turner Ryan, Wang Ying, Chao Raylien, Schulze P Christian, Phipps Kathy, Orwoll Eric, Dam Thuy-Tien
J Clin Endocrinol Metab. 2015 Jun;100(6):2425-33. doi: 10.1210/jc.2014-4180. Epub 2015 Apr 9.
Periodontitis is an inflammatory disease of tooth-supporting tissue leading to bone destruction and tooth loss. Periodontitis affects almost 50% of adults greater than 30 years of age.
This study evaluated the association between biomarkers linked to bone formation and resorption with the occurrence and progression of periodontal disease in older men (≥ 65 y).
The Osteoporotic Fractures in Men (MrOS) study is a prospective, observational study among men 65 years of age and older.
This ancillary study, Oral and Skeletal Bone Loss in Older Men, was conducted at two of the six MrOS study sites (Birmingham, AL and Portland, OR).
Patients underwent medical and dental evaluation. Diagnoses of periodontitis were based on clinical attachment loss, pocket depth, calculus, plaque, and bleeding on a random half-mouth. Bone metabolism biomarkers included serum levels of calcium, phosphate (Pi), alkaline phosphatase, albumin, carboxy-terminal collagen crosslinks (CTX), N-terminal propeptides of type I procollagen, isoform 5b of tartrate-resistant acid phosphatase, and urine alpha- carboxy-terminal collagen crosslinks (alpha-CTX) and beta-CTX and serum levels of calciotropic hormones vitamin D (25(OH)D) and PTH.
The aim of this study is to correlate bone metabolism biomarkers with prevalence and progression of periodontal disease in older men.
Patients with more severe periodontitis had significantly higher levels of PTH (P trend = .0004), whereas 25(OH)D was lower (P trend = .001). In a subset of men reevaluated at a second dental visit, improvement of periodontitis was associated with lower alpha-CTX, beta-CTX, and CTX levels at baseline after adjusting for age, site, and body mass index.
This study suggests that a distinct set of biomarkers of bone metabolism are associated with more severe periodontal disease (PTH, 25(OH)D) and periodontal progression (alpha-CTX, beta-CTX, and CTX) over time.
牙周炎是一种牙齿支持组织的炎症性疾病，可导致骨质破坏和牙齿脱落。牙周炎影响了近50%年龄大于30岁的成年人。
本研究评估了与骨形成和吸收相关的生物标志物与老年男性（≥65岁）牙周疾病发生和进展之间的关联。
男性骨质疏松性骨折（MrOS）研究是一项针对65岁及以上男性的前瞻性观察性研究。
这项辅助研究“老年男性口腔和骨骼骨质流失”在六个MrOS研究地点中的两个进行（阿拉巴马州伯明翰和俄勒冈州波特兰）。
患者接受了医学和牙科评估。牙周炎的诊断基于临床附着丧失、牙周袋深度、牙石、菌斑以及随机半口的出血情况。骨代谢生物标志物包括血清钙、磷酸盐（Pi）、碱性磷酸酶、白蛋白、羧基末端胶原交联（CTX）、I型前胶原N端前肽、抗酒石酸酸性磷酸酶同工型5b，以及尿α-羧基末端胶原交联（α-CTX）和β-CTX，还有促钙激素维生素D（25(OH)D）和甲状旁腺激素（PTH）的血清水平。
本研究的目的是将骨代谢生物标志物与老年男性牙周疾病的患病率和进展情况相关联。
牙周炎更严重的患者甲状旁腺激素水平显著更高（P趋势 = .0004），而25(OH)D水平更低（P趋势 = .001）。在第二次牙科复诊时重新评估的一部分男性中，在调整年龄、研究地点和体重指数后，牙周炎的改善与基线时较低的α-CTX、β-CTX和CTX水平相关。
本研究表明，随着时间推移，一组独特的骨代谢生物标志物与更严重的牙周疾病（甲状旁腺激素（PTH）、25(OH)D）和牙周进展（α-CTX、β-CTX和CTX）相关。
