Gantois Inne, Ducatelle Richard, Pasmans Frank, Haesebrouck Freddy, Gast Richard, Humphrey Tom J, Van Immerseel Filip
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Research Group Veterinary Public Health and Zoonoses, Ghent University, Merelbeke, Belgium.
FEMS Microbiol Rev. 2009 Jul;33(4):718-38. doi: 10.1111/j.1574-6976.2008.00161.x. Epub 2009 Jan 21.
Salmonella Enteritidis (SE) has been the major cause of the food-borne salmonellosis pandemic in humans over the last 20 years, during which contaminated hen's eggs were the most important vehicle of the infection. Eggs can be contaminated on the outer shell surface and internally. Internal contamination can be the result of penetration through the eggshell or by direct contamination of egg contents before oviposition, originating from infection of the reproductive organs. Once inside the egg, the bacteria need to cope with antimicrobial factors in the albumen and vitelline membrane before migration to the yolk can occur. It would seem that serotype Enteritidis has intrinsic characteristics that allow an epidemiological association with hen eggs that are still undefined. There are indications that SE survives the attacks with the help of antimicrobial molecules during the formation of the egg in the hen's oviduct and inside the egg. This appears to require a unique combination of genes encoding for improved cell wall protection and repairing cellular and molecular damage, among others.
肠炎沙门氏菌（SE）在过去20年一直是人类食源性沙门氏菌病大流行的主要病因，在此期间，受污染的鸡蛋是最重要的感染载体。鸡蛋的外壳表面和内部都可能被污染。内部污染可能是由于细菌穿透蛋壳，或在产卵前直接污染蛋清内容物，这源于生殖器官的感染。一旦进入鸡蛋，细菌在迁移到蛋黄之前需要应对蛋清和卵黄膜中的抗菌因子。肠炎血清型似乎具有内在特征，使其与鸡蛋存在尚未明确的流行病学关联。有迹象表明，SE在母鸡输卵管内形成鸡蛋的过程中以及在鸡蛋内部，借助抗菌分子的作用存活下来。这似乎需要一组独特的基因组合，这些基因编码用于改善细胞壁保护以及修复细胞和分子损伤等功能。
