Tae-Yool C, Mizobe T, Nozuchi S, Nakagawa M, Tanaka Y
Department of Anesthesiology, Kyoto Prefectural University of Medicine.
Masui. 1993 May;42(5):721-5.
We have studied the effects of prostaglandin E1 (PGE1) on the release of lysosomal enzymes such as beta-glucuronidase in leukocyte (beta-GL) and granulocyte elastase (GEL) in 52 patients for major abdominal surgery. All patients were divided into two groups; the PG group (24 patients) and the control group (28 patients). The patients of the PG group received PGE1 continuously at the rate of 0.03 to 0.1 micrograms.kg-1.min-1 during surgery. Plasma levels of GEL and beta-GL, which are known to be the indicators of tissue destruction, were measured during and after surgery. The GEL/granulocyte ratio in the PG group was significantly smaller than that of the control group during surgery. The rate of change of beta-GL was significantly depressed in the PG group compared to that of the control group. These findings suggest that the administration of PGE1 during major abdominal surgery inhibits the release of lysosomal enzymes, and this prevents tissue injury during and after surgery.
我们研究了前列腺素E1（PGE1）对52例接受腹部大手术患者白细胞β-葡萄糖醛酸酶（β-GL）和粒细胞弹性蛋白酶（GEL）等溶酶体酶释放的影响。所有患者分为两组：PGE1组（24例）和对照组（28例）。PGE1组患者在手术期间以0.03至0.1微克·千克-1·分钟-1的速率持续输注PGE1。在手术期间和术后测量已知为组织破坏指标的GEL和β-GL的血浆水平。PGE1组手术期间的GEL/粒细胞比率明显低于对照组。与对照组相比，PGE1组β-GL的变化率明显降低。这些发现表明，腹部大手术期间给予PGE1可抑制溶酶体酶的释放，从而预防手术期间及术后的组织损伤。
