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女性生殖道同步性黏液化生与肿瘤形成伴肺转移及STK11/KRAS基因突变:一例报告

Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report.

作者信息

Wang Ru, Yu Hao, Liu Ming, Hao Ting, Wang Xiangyu, Cao Lianbao

机构信息

Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

出版信息

Front Oncol. 2023 Nov 13;13:1246821. doi: 10.3389/fonc.2023.1246821. eCollection 2023.

Abstract

Multiple morphological changes in two or more sites of concurrent multifocal mucinous lesions in the female genital tract are indicative of SMMN-FGT, which is unrelated to high-risk HPV infection. MUC6 and HIK-1083 showed positive characteristic immunohistochemistry. Seldom is the condition described. Here we describe an SMMN-FGT patient who also had lung metastases and STK11/KRAS gene mutations. Based on the current researches, we hypothesize that SMMN-FGT is closely associated with the development of cervical gastric adenocarcinoma.

摘要

女性生殖道同时发生的多灶性黏液性病变在两个或更多部位出现的多种形态学改变提示为女性生殖道同时性黏液性肿瘤(SMMN-FGT),其与高危型人乳头瘤病毒(HPV)感染无关。MUC6和HIK-1083免疫组化表现为阳性特征。该疾病鲜有报道。在此,我们描述了一名同时伴有肺转移和STK11/KRAS基因突变的SMMN-FGT患者。基于目前的研究,我们推测SMMN-FGT与宫颈胃型腺癌的发生密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9bf/10679390/013c8f72b085/fonc-13-1246821-g001.jpg

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