Xu Hongliang, Chen Yong, Zhou Shuguang, Zhao Caixia, Wang Qin, Tang Man, Zhang Weiqin, Zhang Heping
Department of Pathology, Anhui Province Maternity and Child Health Hospital, Anhui Medical University, Hefei, Anhui 230000, P.R. China.
Department of Gynecology, Anhui Province Maternity and Child Health Hospital, Anhui Medical University, Hefei, Anhui 230000, P.R. China.
Exp Ther Med. 2022 Dec 19;25(2):73. doi: 10.3892/etm.2022.11772. eCollection 2023 Feb.
The present study reported a case of Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital Tract (SMMN-FGT), which occurred in a 47-year-old woman. The patient complained of pelvic mass during a physical examination a month ago. Ultrasound examination found an anechoic spot in the left ovary and several anechoic spots were detected in the cervix. The patient underwent left adnexectomy and the left ovarian frozen section revealed a mucinous borderline tumor. Total abdominal hysterectomy and right salpingo-oophorectomy were subsequently performed. Microscopically, multifocal mucinous lesions were involved in the female genital tract, including bilateral ovarian mucinous borderline tumor, cervical and endometrial mucinous adenocarcinoma and the bilateral fallopian tube epithelium showed mucinous metaplasia. Immunohistochemistry revealed that the tumor cells of the ovary, cervix and endometrium expressed MUC6, exhibiting features of gastric-type differentiation. The Ki-67 proliferative index was ~10-70%. Cumulative evidence established SMMN-FGT as the final histopathological diagnosis with International Federation of Gynecology and Obstetrics stage I. Following surgery, the patient received a course of pelvic radiotherapy and survived for 16 months.
本研究报告了一例女性生殖道同步黏液化生和肿瘤形成（SMMN-FGT）病例，该病例发生在一名47岁女性身上。患者在一个月前的体格检查中主诉盆腔肿物。超声检查发现左卵巢有一个无回声区，宫颈发现多个无回声区。患者接受了左附件切除术，左卵巢冰冻切片显示为黏液性交界性肿瘤。随后进行了全腹子宫切除术和右输卵管卵巢切除术。显微镜下，女性生殖道出现多灶性黏液性病变，包括双侧卵巢黏液性交界性肿瘤、宫颈和子宫内膜黏液性腺癌，双侧输卵管上皮显示黏液化生。免疫组织化学显示，卵巢、宫颈和子宫内膜的肿瘤细胞表达MUC6，表现出胃型分化特征。Ki-67增殖指数约为10%-70%。综合证据确定SMMN-FGT为最终组织病理学诊断，国际妇产科联盟分期为I期。手术后，患者接受了一个疗程的盆腔放疗，存活了16个月。
