Fukuda M
Section of Internal Medicine, Nakadori General Hospital.
Rinsho Ketsueki. 1991 Jul;32(7):725-8.
One hundred and thirty-four cases were identified in seven prefectures of the Tohoku district. Fifty-seven per cent of them were over 50 years old, and the incidence had no differences between sexes. They consisted of 51 leukopenia, 32 thrombocytopenia, and nine anemia cases which included seven hemolytic anemia and two pure red cell aplasia. Agents associated with blood dyscrasias were those acting on the central nervous system (CNS) (49 cases), cardiovascular drugs (25 cases), and antimicrobial agents (48 cases). Leukopenia occurred to five patients with cinepazidemaleate (Brendil) administration, 11 with thiamazole (Mercazole), and 14 with antimicrobial agents which were mainly penicillins and cephalosporins. Thrombocytopenia was induced by H2-receptor antagonists (six cases) and antimicrobial agents mostly of penicillins and cephalosporins (12 cases). Anemia contained seven cases of hemolytic anemia, including two patients caused by methyldopa (Aldomet) and two by dried human immunoglobulin (Glovenin). Among 15 cases, 12 out of 19 agents were those affecting the CNS. Six cases were dead from drug-induced blood dyscrasia.
在东北地区的七个县共确诊了134例病例。其中57%的患者年龄超过50岁，发病率在性别上无差异。这些病例包括51例白细胞减少症、32例血小板减少症和9例贫血病例，其中包括7例溶血性贫血和2例纯红细胞再生障碍性贫血。与血液系统疾病相关的药物有作用于中枢神经系统（CNS）的药物（49例）、心血管药物（25例）和抗菌药物（48例）。有5例患者在使用马来酸桂哌齐特（布瑞得）后出现白细胞减少，11例在使用甲巯咪唑（他巴唑）后出现，14例在使用主要为青霉素和头孢菌素的抗菌药物后出现。血小板减少症由H2受体拮抗剂（6例）和主要为青霉素和头孢菌素的抗菌药物（12例）引起。贫血包括7例溶血性贫血，其中2例由甲基多巴（爱道美）引起，2例由冻干人免疫球蛋白（蓉生静丙）引起。在15例病例中，19种药物中有12种是作用于中枢神经系统的药物。有6例患者死于药物性血液系统疾病。
