Murai Y
Tokyo Metropolitan Tama Geriatric Hospital.
Rinsho Ketsueki. 1991 Jul;32(7):721-4.
Ten years experience of 14 hospitals in Kanto district with drug induced blood dyscrasia (DBD) were reviewed. There were 78 patients, male/female ratio was 1:1, and cases more than 80 years old were 10.3%. It was very difficult to identify the causative agents, and only 8 cases were definitive. After disease 9 case were died, and DBD prolonged more than 50 days from onset in 8 patients. Thirty-one patients (39.7%) were due to Antibiotics, beta-lactam were most frequent, 12 cases were due to analgesics, 5 patients were due to thiamazole. In order to elucidate the incidence of DBD, studies had carried out concerning antibiotics and H2 receptor antagonists (H2RA). DBD due to antibiotics increased from 0.5% in 1981 to 4.2% in 1982, because medication of third-generation cephalosporins was began to use. In 109 outpatients with H2RA, there was no DBD, but in 54 hospitalized patients DBD were found in 3.6%. DBD might be more frequent in fact. It is necessary to start big study and to develop new technique for confirmation.
回顾了关东地区14家医院在药物性血细胞减少症（DBD）方面的十年经验。共有78例患者，男女比例为1:1，80岁以上的病例占10.3%。很难确定致病因素，只有8例确诊。发病后9例死亡，8例患者DBD病程从发病起超过50天。31例患者（39.7%）病因是抗生素，其中β-内酰胺类最为常见，12例病因是镇痛药，5例患者病因是甲巯咪唑。为了阐明DBD的发病率，已针对抗生素和H2受体拮抗剂（H2RA）开展了研究。由于开始使用第三代头孢菌素，抗生素所致的DBD从1981年的0.5%增至1982年的4.2%。在109例使用H2RA的门诊患者中未发现DBD，但在54例住院患者中发现DBD的比例为3.6%。实际上DBD可能更为常见。有必要开展大规模研究并开发新的确诊技术。
