Maekawa I
Dep. Inntern. Med. Asahikawa City Hospital.
Rinsho Ketsueki. 1991 Jul;32(7):729-33.
Patients with drug-induced hematologic disorders were clinically analysed. Fifty-nine cases were registered from 6 hospitals in Hokkaido. These were 21 cases of male and 38 of female. Age-distribution was 18 to 84 years old. Types of hematologic disorders were as follows, 9 cases of pancytopenia, 16 of bicytopenia and 31 of monocytopenia. Leukocytopenia only and leukocytopenia with another disorders were high incidence (85%). Decision of causal drug are done by DLST (drug lymphocyte stimulation test); 5 cases, drug-rechallenge; 3 cases and clinical course only; 31 cases. In 11 fatal cases by this lesion, there included 7 cases of pancytopenia.
对药物性血液系统疾病患者进行了临床分析。从北海道的6家医院登记了59例病例。其中男性21例，女性38例。年龄分布为18至84岁。血液系统疾病类型如下：全血细胞减少症9例，二系血细胞减少症16例，单系血细胞减少症31例。单纯白细胞减少症和伴有其他疾病的白细胞减少症发病率较高（85%）。通过药物淋巴细胞刺激试验（DLST）确定致病药物；5例，药物再激发试验；3例，仅依据临床病程；31例。在因该病变导致的11例死亡病例中，包括7例全血细胞减少症。
