Antioxidant and antiradical activities of resorcinarene tetranitroxides.

作者信息

Vovk Andriy I, Shivanyuk Alexander M, Bugas Roman V, Muzychka Oxana V, Melnyk Andriy K

机构信息

Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska, 1, 02660 Kyiv-94, Ukraine.

出版信息

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1314-7. doi: 10.1016/j.bmcl.2009.01.070. Epub 2009 Jan 27.

DOI:10.1016/j.bmcl.2009.01.070

PMID:19208474

Abstract

Resorcinarene oxazines bearing four TEMPO fragments at the wide rim of the macrocycle were prepared through the aminomethylation of resorcinarene octols with 4-amino-TEMPO and formaldehyde. Tetra-TEMPO resorcinarenes are efficient scavengers of 1,1-diphenyl-2-picrylhydrazyl radicals. The model studies revealed that macrocyclic structure and intramolecular hydrogen bonding make considerable contribution to antiradical activity of these compounds. Tetra-TEMPO resorcinarenes show also superoxide dismutase-like activity and efficiently inhibit ABAP-induced peroxidation of linoleic acid.

摘要