性别对大型观察性队列中类风湿关节炎患者的影响。
The influence of sex on patients with rheumatoid arthritis in a large observational cohort.
作者信息
Iikuni Noriko, Sato Eri, Hoshi Masaya, Inoue Eisuke, Taniguchi Atsuo, Hara Masako, Tomatsu Taisuke, Kamatani Naoyuki, Yamanaka Hisashi
机构信息
University of California, Los Angeles, Department of Medicine, Los Angeles, CA 90095, USA.
出版信息
J Rheumatol. 2009 Mar;36(3):508-11. doi: 10.3899/jrheum.080724. Epub 2009 Feb 4.
OBJECTIVE
To compare the sex differences of various components of rheumatoid arthritis (RA).
METHODS
Data of 4823 patients from a large observational cohort study were analyzed. Remarkable differences were noted between the sexes, and overall, women had significantly higher disease activity.
RESULTS
When variables were adjusted using sex, age, and duration, Health Assessment Questionnaire, rather than Disease Activity Score, contributed most to sex difference. Further analysis showed evidence that progression of disability was approximately 3 times more rapid in female patients compared to male patients.
CONCLUSION
Women overall have higher RA disease activity and are prone to greater and faster progression of disability over time.
目的
比较类风湿关节炎（RA）各组成部分的性别差异。
方法
分析了一项大型观察性队列研究中4823例患者的数据。两性之间存在显著差异，总体而言，女性的疾病活动度明显更高。
结果
当使用性别、年龄和病程进行变量调整时，健康评估问卷而非疾病活动评分对性别差异的影响最大。进一步分析表明，与男性患者相比，女性患者残疾进展速度快约3倍。
结论
总体而言，女性的类风湿关节炎疾病活动度更高，且随着时间的推移，残疾程度更严重、进展更快。
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