痴呆患者事件相关电位的分布
Distribution of event-related potentials in patients with dementia.
作者信息
Yokoyama Y, Nakashima K, Shimoyama R, Urakami K, Takahashi K
机构信息
Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
出版信息
Electromyogr Clin Neurophysiol. 1995 Nov;35(7):431-7.
Distributions of the amplitudes and the latencies of N100, P200, N200, P300 and mismatch negativity (MMN) were studied. The P300 latency was delayed in patients with dementia of the Alzheimer type (DAT) and patients with vascular dementia (VD). The N200 latency was delayed on Pz in DAT patients, and on Fz in VD patients. MMN latency was delayed on Pz in DAT patients. The P300 amplitude was low on Pz in DAT patients. The N100 amplitude was low in VD patients on Pz. These findings show the difference in cerebral lesions between DAT and VD. We suggest that studies of P300 amplitude, N200 latency, MMN latency and N100 amplitude distribution would be useful in differential diagnosis in patients with dementia.
研究了N100、P200、N200、P300和失配负波（MMN）的波幅和潜伏期分布。阿尔茨海默型痴呆（DAT）患者和血管性痴呆（VD）患者的P300潜伏期延迟。DAT患者在Pz点的N200潜伏期延迟，VD患者在Fz点的N200潜伏期延迟。DAT患者在Pz点的MMN潜伏期延迟。DAT患者在Pz点的P300波幅较低。VD患者在Pz点的N100波幅较低。这些发现表明DAT和VD在脑损伤方面存在差异。我们认为，研究P300波幅、N200潜伏期、MMN潜伏期和N100波幅分布对痴呆患者的鉴别诊断有帮助。
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