Curran P F, Taylor A E, Solomon A K
Biophysical Laboratory, Harvard Medical School, Boston, MA 2115, USA; and Department of Physiology, Yale University School of Medicine, New Haven CT, 06510, USA.
Biophys J. 1967 Nov;7(6):879-901. doi: 10.1016/S0006-3495(67)86627-X. Epub 2008 Dec 31.
Available experimental data have been utilized to examine the effects of cross-coefficients on tracer diffusion and on the estimation of unidirectional fluxes from observations on tracer flow. In free solution or in a nonselective membrane, the interaction between the flows of tracer and the unlabelled substance are small at concentrations of biological interest for the nonelectrolytes urea, alanine, and beta-alanine, and for sodium and chloride ions. Under these conditions, measurement of tracer flow can be used to predict flow of the bulk substance to an accuracy of a few per cent.
现有的实验数据已被用于检验交叉系数对示踪剂扩散以及根据示踪剂流动观测值估算单向通量的影响。在自由溶液或非选择性膜中，对于非电解质尿素、丙氨酸和β-丙氨酸以及钠离子和氯离子，在具有生物学意义的浓度下，示踪剂流与未标记物质流之间的相互作用很小。在这些条件下，示踪剂流动的测量可用于预测大量物质的流动，其准确度可达百分之几。
