Gary-Bobo C M, DiPolo R, Solomon A K
J Gen Physiol. 1969 Sep;54(3):369-82. doi: 10.1085/jgp.54.3.369.
The diffusion of two series of alcohols and amides through complex cellulose acetate membranes was studied. The thin dense part of these membranes behaves as a nonporous layer of low water content. In this layer, called the skin, the solute diffusion coefficients, omega, depend upon size, steric configuration, and the partition coefficient, K(8), between membrane and bathing solution. From the experimental values of omega and K(8), the over-all friction, f, experienced by the solutes in the membrane was computed. It was found that f depends upon the chemical nature of the solute and is related to hydrogen-bonding ability. In the coarse, porous layer of the cellulose acetate membrane, diffusion occurs mainly through aqueous channels. In this instance also the hydrogen-bonding ability of the solute seems to exercise a smaller but significant influence.
研究了两类醇和酰胺通过复合醋酸纤维素膜的扩散情况。这些膜的致密薄层表现为低含水量的无孔层。在这个称为皮层的层中，溶质扩散系数ω取决于溶质的大小、空间构型以及膜与浸泡溶液之间的分配系数K(8)。根据ω和K(8)的实验值，计算了溶质在膜中所经历的总摩擦系数f。结果发现，f取决于溶质的化学性质，并且与氢键形成能力有关。在醋酸纤维素膜的粗糙多孔层中，扩散主要通过水通道进行。在这种情况下，溶质的氢键形成能力似乎也发挥了较小但显著的影响。
