Parmentier H K, Rodenburg T B, De Vries Reilingh G, Beerda B, Kemp B
Adaptation Physiology Group, Department of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, the Netherlands.
Poult Sci. 2009 Mar;88(3):536-42. doi: 10.3382/ps.2008-00424.
To mimic airborne immune challenges, layer hens were intratracheally and concurrently challenged with various doses of the protein antigen human serum albumin (HuSA) and the pathogen-associated molecular pattern lipopolysaccharide (LPS) at 7 and 13 wk of age. All groups received 1 similar dose of HuSA plus LPS at 11 mo of age. Evaluation of plumage and body condition at 12 mo of age revealed that birds that had undergone intratracheal immunization with a high dosage of HuSA, irrespective of the concurrent dose of LPS, had significantly more feather damage but less wounds to the vent region, as opposed to birds not receiving HuSA. On the other hand, a high dosage of LPS was related to comb damage. These results suggest that stimulation of specific (humoral) immune responses (to HuSA) rather than innate responses (to LPS) at a young age may predispose layers for feather pecking (FP) behavior at later ages. Involvement of immune mechanisms in FP or vent damage may differ. Predisposal for FP behavior by specific immunity can have consequences for health and vaccine management.
为模拟空气传播的免疫挑战，在7周龄和13周龄时，对蛋鸡进行气管内接种，并同时用不同剂量的蛋白质抗原人血清白蛋白（HuSA）和病原体相关分子模式脂多糖（LPS）进行攻击。所有组在11月龄时接受1个相似剂量的HuSA加LPS。对12月龄时的羽毛和身体状况评估显示，无论同时接种的LPS剂量如何，接受高剂量HuSA气管内免疫的鸡只，与未接受HuSA的鸡只相比，羽毛损伤明显更多，但泄殖腔区域伤口更少。另一方面，高剂量的LPS与鸡冠损伤有关。这些结果表明，幼年时刺激特异性（体液）免疫反应（针对HuSA）而非先天免疫反应（针对LPS），可能使蛋鸡在后期更容易出现啄羽（FP）行为。免疫机制在FP或泄殖腔损伤中的作用可能不同。特异性免疫对FP行为的易感性可能会对健康和疫苗管理产生影响。
