College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723001, China.
Shaanxi Province Key Laboratory of Bio-Resources, Shaanxi University of Technology, Hanzhong 723001, China.
Molecules. 2024 Nov 5;29(22):5226. doi: 10.3390/molecules29225226.
Skin photoaging, primarily caused by ultraviolet (UV) radiation, leads to skin metabolic disorders, which have adverse psychological and physiological effects on individuals. However, traditional medications for repairing skin photoaging cause side effects. Natural bioactive compounds have been shown to prevent and treat skin photoaging with fewer side effects. Epigallocatechin gallate (EGCG), the main substance in tea polyphenols, is a natural bioactive compound with a range of properties. This review summarizes the beneficial effects and mechanisms of EGCG, as well as the application forms of EGCG in repairing photoaged skin. Results indicated that EGCG has repair effects, including improving elasticity, enhancing moisturization, inhibiting damage, and reducing pigmentation of photoaged skin. It has also been demonstrated that EGCG delivery systems, modified EGCG, and combinations with other bioactive substances could be used for repairing photoaged skin due to its poor stability and low bioavailability. EGCG effectively repairs various types of skin damage caused by UV radiation while maintaining normal skin structure and function. It is, therefore, an effective candidate for repairing photoaged skin. These results could provide references for the development and application of EGCG products for the treatment of photoaged skin.
皮肤光老化主要由紫外线（UV）辐射引起，导致皮肤代谢紊乱，对个体产生不良的心理和生理影响。然而，传统的修复皮肤光老化的药物会引起副作用。天然生物活性化合物已被证明可以预防和治疗皮肤光老化，且副作用较少。表没食子儿茶素没食子酸酯（EGCG）是茶多酚中的主要物质，是一种具有多种特性的天然生物活性化合物。本综述总结了 EGCG 的有益作用和作用机制，以及 EGCG 在修复光老化皮肤中的应用形式。结果表明，EGCG 具有修复作用，包括改善弹性、增强保湿、抑制损伤和减少光老化皮肤的色素沉着。此外，由于 EGCG 稳定性差、生物利用度低，其递送系统、改性 EGCG 以及与其他生物活性物质的组合也可用于修复光老化皮肤。EGCG 可有效修复各种由 UV 辐射引起的皮肤损伤，同时保持正常的皮肤结构和功能。因此，它是修复光老化皮肤的有效候选物。这些结果可为开发和应用 EGCG 产品治疗光老化皮肤提供参考。
