Suppr超能文献

随机临床试验中二元比例多对一比较的渐近同时置信区间。

Asymptotic simultaneous confidence intervals for many-to-one comparisons of binary proportions in randomized clinical trials.

作者信息

Schaarschmidt Frank, Biesheuvel Egbert, Hothorn Ludwig A

机构信息

Institute of Biostatistics, Leibniz Universitat Hannover, Germany.

出版信息

J Biopharm Stat. 2009;19(2):292-310. doi: 10.1080/10543400802622501.

Abstract

The simultaneous comparison of proportions of success between many treatments and one control group is a common problem in randomized clinical trials or toxicity studies. In this article, three recently recommended asymptotic confidence interval approaches for the difference of proportions are adjusted for multiplicity, taking the correlation into account. The coverage probability of the resulting interval methods is compared in a simulation study using parameter settings relevant for clinical trials. For moderate to small sample sizes, a method adding two successes and two failures can be recommended. The usage of the proposed methods is illustrated by two examples; an R package is available.

摘要

在随机临床试验或毒性研究中,同时比较多种治疗方法与一个对照组之间的成功比例是一个常见问题。在本文中,针对比例差异的三种最近推荐的渐近置信区间方法进行了多重性调整,并考虑了相关性。在使用与临床试验相关的参数设置的模拟研究中,比较了所得区间方法的覆盖概率。对于中到小样本量,可以推荐一种添加两个成功和两个失败的方法。通过两个例子说明了所提出方法的用法;有一个R包可供使用。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验