Bosetti Cristina, Gallus Silvano, La Vecchia Carlo
Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
Recent Results Cancer Res. 2009;181:231-51. doi: 10.1007/978-3-540-69297-3_22.
Aspirin has been associated with a reduced risk of colorectal cancer and--based on limited evidence--to cancers of the oesophagus, stomach, breast, ovary and lung. The role of aspirin on other cancers, such as pancreatic, prostate and bladder cancer and non-Hodgkin's lymphomas and myeloma is less clear, and an increase of risk has been suggested for kidney cancer. For most cancer sites, however, significant heterogeneity between studies, and particularly between study design, was found, with a reduction in risk generally stronger in case-control studies than in cohort ones.
阿司匹林与降低结直肠癌风险相关,并且——基于有限的证据——与食管癌、胃癌、乳腺癌、卵巢癌和肺癌风险降低也相关。阿司匹林对其他癌症的作用,如胰腺癌、前列腺癌、膀胱癌、非霍奇金淋巴瘤和骨髓瘤,尚不太明确,且有研究表明其会增加肾癌风险。然而,对于大多数癌症部位,研究之间,尤其是研究设计之间,存在显著的异质性,一般而言,病例对照研究中风险降低的程度比队列研究更强。