儿科血液肿瘤患者人群中人类偏肺病毒医院感染暴发的分子流行病学调查
Molecular epidemiological investigation of a nosocomial outbreak of human metapneumovirus infection in a pediatric hemato-oncology patient population.
作者信息
Kim Sollip, Sung Heungsup, Im Ho Joon, Hong Soo-Jong, Kim Mi-Na
机构信息
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
出版信息
J Clin Microbiol. 2009 Apr;47(4):1221-4. doi: 10.1128/JCM.01959-08. Epub 2009 Feb 11.
Abstract
We report the first nosocomial outbreak of human metapneumovirus (hMPV) infection in a pediatric patient population. Among 15 pediatric hMPV infections from March to May 2007, there was a nosocomial outbreak involving two patients sharing a room in a hemato-oncology ward with a patient with a community-acquired case of hMPV infection. The estimated incubation period was 7 to 9 days for a symptomatic nosocomial case. Sequencing of fusion genes of 15 isolates revealed two clusters belonging to subgroup A2 and one cluster belonging to subgroup B2. Three isolates from the outbreak had sequences identical to those of samples in the A2 cluster. There was also a separate nosocomial case represented by the B2 cluster.
摘要
我们报告了在儿科患者群体中首次发生的人偏肺病毒（hMPV）医院感染暴发。在2007年3月至5月期间的15例儿科hMPV感染病例中，发生了一起医院感染暴发，涉及血液肿瘤科病房中同住一室的两名患者，其中一名患者为社区获得性hMPV感染病例。有症状的医院感染病例的估计潜伏期为7至9天。对15株分离株的融合基因进行测序，发现两个属于A2亚组的簇和一个属于B2亚组的簇。暴发中的三株分离株与A2簇中的样本序列相同。还有一例由B2簇代表的单独的医院感染病例。
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