Department of Family Medicine and Community Health, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Epidemiol Infect. 2024 May 21;152:e90. doi: 10.1017/S0950268824000517.
We analyzed data from a community-based acute respiratory illness study involving K-12 students and their families in southcentral Wisconsin and assessed household transmission of two common seasonal respiratory viruses - human metapneumovirus (HMPV) and human coronaviruses OC43 and HKU1 (HCOV). We found secondary infection rates of 12.2% (95% CI: 8.1%-17.4%) and 19.2% (95% CI: 13.8%-25.7%) for HMPV and HCOV, respectively. We performed individual- and family-level regression models and found that HMPV transmission was positively associated age of the index case (individual model: = .016; family model: = .004) and HCOV transmission was positively associated with household density (family model: = .048). We also found that the age of the non-index case was negatively associated with transmission of both HMPV (individual model: = .049) and HCOV (individual model: = .041), but we attributed this to selection bias from the original study design. Understanding household transmission of common respiratory viruses like HMPV and HCOV may help to broaden our understanding of the overall disease burden and establish methods to prevent the spread of disease from low- to high-risk populations.
我们分析了威斯康星州中南部地区一项基于社区的急性呼吸道疾病研究中 K-12 学生及其家庭的数据，并评估了两种常见季节性呼吸道病毒——人偏肺病毒（HMPV）和人类冠状病毒 OC43 和 HKU1（HCOV）在家庭中的传播情况。我们发现 HMPV 和 HCOV 的继发感染率分别为 12.2%（95%CI：8.1%-17.4%）和 19.2%（95%CI：13.8%-25.7%）。我们进行了个体和家庭水平的回归模型分析，发现 HMPV 的传播与指数病例的年龄呈正相关（个体模型：=0.016；家庭模型：=0.004），而 HCOV 的传播与家庭密度呈正相关（家庭模型：=0.048）。我们还发现，非指数病例的年龄与 HMPV（个体模型：=0.049）和 HCOV（个体模型：=0.041）的传播均呈负相关，但我们认为这是由于原始研究设计的选择偏差所致。了解 HMPV 和 HCOV 等常见呼吸道病毒的家庭传播情况，可能有助于我们更全面地了解整体疾病负担，并制定预防疾病从低风险人群向高风险人群传播的方法。
