Ciosek P, Zawadzki K, Łopacińska J, Skolimowski M, Bembnowicz P, Golonka L J, Brzózka Z, Wróblewski W
Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664, Warsaw, Poland.
Anal Bioanal Chem. 2009 Apr;393(8):2029-38. doi: 10.1007/s00216-009-2651-x. Epub 2009 Feb 14.
Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. In this work a novel tool based on a miniaturized sensor array fabricated using low-temperature cofired ceramics (LTCC) technology is presented. The developed device is applied to the monitoring of cell-culture media change, detection of the growth of various species, and in toxicological studies performed with the use of cells. Noninvasive monitoring performed with the LTCC microelectrode array can be applied for future cell-engineering purposes.
在微生物反应器中监测细胞培养是细胞生物测定和毒理学测试中的一项关键任务。在这项工作中，提出了一种基于使用低温共烧陶瓷（LTCC）技术制造的小型化传感器阵列的新型工具。所开发的设备应用于监测细胞培养基变化、检测各种物种的生长以及在使用细胞进行的毒理学研究中。利用LTCC微电极阵列进行的非侵入性监测可用于未来的细胞工程目的。
