Muenter M D, Daube J R, Caviness J N, Miller P M
Lee Silverman Center for Parkinson's Disease and Movement Disorders, Mayo Clinic Scottsdale, AZ 85259.
Mayo Clin Proc. 1991 Oct;66(10):991-7. doi: 10.1016/s0025-6196(12)61721-2.
We treated 28 patients (16 women and 12 men) who had essential tremor with methazolamide. Their median age was 69 years (range, 34 to 89 years), and the median duration of tremor was 16 years (range, less than 1 to 69 years). Fifteen cases were familial and 13 were sporadic. Improvement in 10 patients who continued taking the drug ranged from moderate to complete relief. In addition, four patients had marked improvement and two had moderate improvement but discontinued use of the drug because of side effects. Five patients with a mild response and seven with no response also discontinued methazolamide therapy. The maximal mean daily dose was 203 mg for all patients and 129 mg (maintenance dose) for the patients who continued taking the drug. Side effects consisted primarily of somnolence, nausea, epigastric discomfort, anorexia, paresthesias, and numbness. No aplastic anemia was noted in any of the patients. The median duration of follow-up was 6 months (range, 10 weeks to 29 months). The therapeutic effect seemed unrelated to a family history of tremor, the effect of alcohol, or the responsiveness to propranolol or primidone. Methazolamide may be an effective drug in the treatment of some patients with essential tremor, particularly those with head and voice tremor.
我们用甲醋唑胺治疗了28例特发性震颤患者（16例女性，12例男性）。他们的年龄中位数为69岁（范围34至89岁），震颤持续时间中位数为16年（范围不到1年至69年）。15例为家族性，13例为散发性。继续服药的10例患者的症状改善程度从中度到完全缓解不等。此外，4例患者有明显改善，2例有中度改善，但因副作用而停药。5例反应轻微和7例无反应的患者也停止了甲醋唑胺治疗。所有患者的最大平均日剂量为203毫克，继续服药的患者为129毫克（维持剂量）。副作用主要包括嗜睡、恶心、上腹部不适、厌食、感觉异常和麻木。所有患者均未出现再生障碍性贫血。随访时间中位数为6个月（范围10周 至29个月）。治疗效果似乎与震颤家族史、酒精的影响或对普萘洛尔或扑米酮的反应性无关。甲醋唑胺可能是治疗某些特发性震颤患者的有效药物，尤其是那些伴有头部和声音震颤的患者。
