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巴西南部南里奥格兰德州人群中15个STR基因座频率及突变率。

15 STR loci frequencies with mutation rates in the population from Rio Grande do Sul, Southern Brazil.

作者信息

Chula Fernanda Goulart Lanes, Rodenbusch Rodrigo, Schumacher Simone, Grandi Tarciana, Michelon Candice Tosi, Gastaldo André Zoratto, Costi Cíntia, Carvalho Bianca, da Silva Cláudia Maria Dornelles

机构信息

Laboratório de Investigação de Paternidade, Centro de Desenvolvimento Científico e Tecnológico, Fundação Estadual de Produção e Pesquisa em Saúde, Av. Ipiranga, 5400, Bairro Jardim Botânico, CEP 90610-000 Porto Alegre, RS, Brazil.

出版信息

Forensic Sci Int Genet. 2009 Mar;3(2):e35-8. doi: 10.1016/j.fsigen.2008.05.006. Epub 2008 Jul 3.

DOI:10.1016/j.fsigen.2008.05.006
PMID:19215864
Abstract

Allele frequencies for 15 short tandem repeats (STR) loci were obtained from a sample of 2038 individuals undergoing paternity testing. The population is from Rio Grande do Sul, Brazil. The loci are the most commonly used in forensic and paternity testing, being analysed by the AmpFlSTR Identifiler (Applied Biosystems) commercial kit. The most polymorphic locus was D2S1338. Mutation rates were ascertained from this population sample. All the loci analysed reached the Hardy-Weinberg equilibrium. The results of genetic distance are consistent with the European-derived origins of Rio Grande do Sul population.

摘要

从2038名接受亲子鉴定的个体样本中获取了15个短串联重复序列(STR)位点的等位基因频率。该人群来自巴西南里奥格兰德州。这些位点是法医和亲子鉴定中最常用的,通过AmpFlSTR Identifiler(应用生物系统公司)商业试剂盒进行分析。多态性最高的位点是D2S1338。从该人群样本中确定了突变率。所有分析的位点均达到哈迪-温伯格平衡。遗传距离的结果与南里奥格兰德州人群源自欧洲的起源一致。

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