Rarey K E, Lohuis P J, ten Cate W J
Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville 32610.
Laryngoscope. 1991 Oct;101(10):1081-4. doi: 10.1288/00005537-199110000-00009.
Structural changes in the cellular architecture of the stria vascularis in adrenalectomized rats were quantitated by stereological methods after the administration of either aldosterone or dexamethasone. The volume densities of the differing strial components from steroid-administered animals were determined to approximate those of sham-adrenalectomized animals in general. The increased volume density of intercellular space as was observed following adrenalectomy, however, was only restored after the administration of aldosterone. These data correlate a recovery of the cellular architecture of the stria vascularis in adrenalectomized animals with the restoration of endogenous levels of adrenal steroids. These findings provide further information with regard to the effects of varying serum levels of corticosteroids on inner ear morphology.
通过体视学方法对肾上腺切除大鼠给予醛固酮或地塞米松后血管纹细胞结构的变化进行定量分析。一般来说，给予类固醇的动物不同纹状体成分的体积密度被确定为接近假肾上腺切除动物的体积密度。然而，肾上腺切除后观察到的细胞间隙体积密度增加，只有在给予醛固酮后才得以恢复。这些数据将肾上腺切除动物血管纹细胞结构的恢复与肾上腺类固醇内源性水平的恢复联系起来。这些发现为不同血清皮质类固醇水平对内耳形态的影响提供了进一步的信息。
