Miyamori I, Takeda Y, Yoneda T, Iki K, Takeda R
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Life Sci. 1991;49(18):1295-300. doi: 10.1016/0024-3205(91)90193-f.
We measured the ET-1 concentration in plasma and in the perfusate of the mesenteric arteries of rats treated with a therapeutic dose of IL-2 for 7 days (100000 U/Kg, iv.). The plasma ET-1 concentration in rats given IL-2 was 14.2 +/- 3.2 pg/ml which was significantly greater than that in the controls (2.5 +/- 0.4 pg/ml, P less than 0.05). The mesenteric arteries also released a significantly greater amount of ET-1 (29.5 +/- 1.6 pg/h) than that in controls (16.8 +/- 2.3 pg/h, P less than 0.01). The arterial blood pressure was significantly lower after IL-2 treatment than the pre-dosing level (P less than 0.05). It is concluded that IL-2 induces ET-1 release from the vascular wall, possibly as a result of reversible endothelial dysfunction caused by IL-2.
我们测量了用治疗剂量的白细胞介素 -2（100000 U/Kg，静脉注射）处理7天的大鼠血浆和肠系膜动脉灌流液中内皮素 -1（ET -1）的浓度。给予白细胞介素 -2的大鼠血浆ET -1浓度为14.2±3.2 pg/ml，显著高于对照组（2.5±0.4 pg/ml，P＜0.05）。肠系膜动脉释放的ET -1量（29.5±1.6 pg/h）也显著高于对照组（16.8±2.3 pg/h，P＜0.01）。白细胞介素 -2处理后动脉血压显著低于给药前水平（P＜0.05）。结论是白细胞介素 -2诱导血管壁释放ET -1，这可能是白细胞介素 -2引起的可逆性内皮功能障碍的结果。
