Takeda Y, Miyamori I, Yoneda T, Takeda R
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Eur J Pharmacol. 1992 Mar 31;213(3):445-7. doi: 10.1016/0014-2999(92)90635-h.
The release of endothelin-1 from mesenteric arteries from cyclosporine-treated rats was measured by a specific enzyme immunoassay after purification of the perfusate on an immunoaffinity column. Mesenteric arteries from cyclosporine-treated rats (25 mg/kg per day for 6 weeks) released a significantly larger amount of endothelin-1 than arteries from vehicle-treated control rats (P less than 0.05). Serum creatinine levels were not significantly different in the two groups. These findings indicate that cyclosporine is a potential inducer of endothelin release from the mesenteric artery.
通过免疫亲和柱对灌注液进行纯化后，采用特异性酶免疫测定法测量经环孢素处理的大鼠肠系膜动脉中内皮素-1的释放量。经环孢素处理的大鼠（每天25mg/kg，持续6周）的肠系膜动脉释放的内皮素-1量显著多于经载体处理的对照大鼠的动脉（P小于0.05）。两组的血清肌酐水平无显著差异。这些发现表明，环孢素是肠系膜动脉内皮素释放的潜在诱导剂。
