评估常见载脂蛋白A2变体与2型糖尿病之间的关联。
Evaluating the association of common APOA2 variants with type 2 diabetes.
作者信息
Duesing Konsta, Charpentier Guillaume, Marre Michel, Tichet Jean, Hercberg Serge, Balkau Beverley, Froguel Philippe, Gibson Fernando
机构信息
Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London, W12 0NN, UK.
出版信息
BMC Med Genet. 2009 Feb 13;10:13. doi: 10.1186/1471-2350-10-13.
BACKGROUND
APOA2 is a positional and biological candidate gene for type 2 diabetes at the chromosome 1q21-q24 susceptibility locus. The aim of this study was to examine if HapMap phase II tag SNPs in APOA2 are associated with type 2 diabetes and quantitative traits in French Caucasian subjects.
METHODS
We genotyped the three HapMap phase II tagging SNPs (rs6413453, rs5085 and rs5082) required to capture the common variation spanning the APOA2 locus in our type 2 diabetes case-control cohort comprising 3,093 French Caucasian subjects. The association between these variants and quantitative traits was also examined in the normoglycaemic adults of the control cohort. In addition, meta-analysis of publicly available whole genome association data was performed.
RESULTS
None of the APOA2 tag SNPs were associated with type 2 diabetes in the French Caucasian case-control cohort (rs6413453, P = 0.619; rs5085, P = 0.245; rs5082, P = 0.591). However, rs5082 was marginally associated with total cholesterol levels (P = 0.026) and waist-to-hip ratio (P = 0.029). The meta-analysis of data from 12,387 subjects confirmed our finding that common variation at the APOA2 locus is not associated with type 2 diabetes.
CONCLUSION
The available data does not support a role for common variants in APOA2 on type 2 diabetes susceptibility or related quantitative traits in Northern Europeans.
背景
载脂蛋白A2（APOA2）是位于1号染色体1q21 - q24易感位点的2型糖尿病的定位和生物学候选基因。本研究旨在探讨APOA2基因中HapMap二期标签单核苷酸多态性（SNP）是否与法国白种人受试者的2型糖尿病及数量性状相关。
方法
我们对3093名法国白种人2型糖尿病病例对照队列中捕获APOA2基因座常见变异所需的3个HapMap二期标签SNP（rs6413453、rs5085和rs5082）进行基因分型。还在对照队列的血糖正常成年人中研究了这些变异与数量性状之间的关联。此外，对公开可用的全基因组关联数据进行了荟萃分析。
结果
在法国白种人病例对照队列中，APOA2标签SNP均与2型糖尿病无关（rs6413453，P = 0.619；rs5085，P = 0.245；rs5082，P = 0.591）。然而，rs5082与总胆固醇水平（P = 0.026）和腰臀比（P = 0.029）存在边缘关联。对12387名受试者数据的荟萃分析证实了我们的发现，即APOA2基因座的常见变异与2型糖尿病无关。
结论
现有数据不支持APOA2常见变异在北欧人2型糖尿病易感性或相关数量性状中起作用。
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