Nurata Hakan, Cemil Berker, Kurt Gökhan, Uçankuş Neşe Lortlar, Dogulu Fikret, Omeroğlu Suna
Department of Neurosurgery, Ergani State Hospital, Ergani, Diyarbakir, Turkey.
J Clin Neurosci. 2009 Apr;16(4):542-4. doi: 10.1016/j.jocn.2008.05.021. Epub 2009 Feb 12.
We conducted a study to determine the effectiveness of topically applied recombinant mouse fibroblast growth factor-2 (FGF-2) in healing the dura mater in a rat with dura mater injury and cerebrospinal fluid leakage. Laminectomies were performed in 32 rats at the level of the L2-L4 vertebrae, and a dura mater defect was created. Sixteen rats were treated postoperatively with locally applied recombinant mouse FGF-2, and 16 animals received normal saline. FGF-2 effects on dura mater healing, cerebrospinal fluid leakage, and wound healing were assessed at 3 and 6 weeks postoperatively. The extent of dura mater healing was evaluated by histological analysis. We found that dura mater healing was significantly increased (p<0.05) in rats treated with FGF-2 compared with rats in the control group. In this experimental model, locally applied FGF-2 effectively increased dura mater healing and induced no side effects.
我们进行了一项研究，以确定局部应用重组小鼠成纤维细胞生长因子-2（FGF-2）对硬脑膜损伤并伴有脑脊液漏的大鼠硬脑膜愈合的有效性。在32只大鼠的L2-L4椎体水平进行椎板切除术，并制造硬脑膜缺损。16只大鼠术后局部应用重组小鼠FGF-2进行治疗，另外16只动物接受生理盐水处理。在术后3周和6周评估FGF-2对硬脑膜愈合、脑脊液漏和伤口愈合的影响。通过组织学分析评估硬脑膜愈合的程度。我们发现，与对照组大鼠相比，用FGF-2治疗的大鼠硬脑膜愈合显著增加（p<0.05）。在该实验模型中，局部应用FGF-2可有效促进硬脑膜愈合且未引起副作用。
