血管腔形成的细胞和分子机制。

Iruela-Arispe M Luisa, Davis George E

Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, 90095, USA.

Dev Cell. 2009 Feb;16(2):222-31. doi: 10.1016/j.devcel.2009.01.013.

The formation of vascular lumens by endothelial cells is a critical step in the angiogenic process that occurs during invasion and growth of the incipient vascular sprout. Once a lumen is established, capillaries are rapidly exposed to the physical forces associated with the flow of blood which, together with genetic information, regulate the ultimate size of inner vessel diameter. Here we review the recent literature on vascular lumen formation and compare it to lumen formation in other epithelial systems. We also discuss the regulation of lumen diameter after vascular morphogenesis has been completed.

内皮细胞形成血管腔是血管生成过程中的关键步骤，该过程发生在新生血管芽的侵袭和生长期间。一旦建立起管腔，毛细血管就会迅速暴露于与血流相关的物理力之下，这些物理力与遗传信息共同调节血管内径的最终大小。在此，我们综述了有关血管腔形成的最新文献，并将其与其他上皮系统中的管腔形成进行比较。我们还讨论了血管形态发生完成后管腔直径的调节。