Coban Ibrahim, Satoğlu Ismail Safa, Gültekin Alper, Tuna Burçin, Tatari Hasan, Fidan Mustafa
Dokuz Eylül University, School of Medicine, Department of Orthopaedics and Traumatology, Izmir, Turkey.
Foot Ankle Surg. 2009;15(1):22-7. doi: 10.1016/j.fas.2008.06.005. Epub 2008 Jul 31.
To determine the effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures, 72 tendons of 36 Wistar rats were injected with betamethasone sodium phosphate.
By the end of fourth week, both tendons were tenotomized and repaired, then the samples were divided into three groups. The first group was left untreated after suturing. Human amniotic fluid was injected to the second and amniotic fluid and membrane were both administered to the third group. Twenty-four tendons were scored at the end of the first week, and 24 at the end of the second week histopathologically, and 24 biomechanically at the end of the third week.
There was a significant statistical difference only between the histopathological results of Groups 2 and 3 at the first week.
Human amniotic membrane and fluid do not add anything to the healing process of Achilles tendon ruptures in the early phase.
为了确定人羊水和羊膜在治疗跟腱断裂中的作用，对36只Wistar大鼠的72条肌腱注射了磷酸倍他米松钠。
在第四周结束时，将两条肌腱切断并修复，然后将样本分为三组。第一组缝合后不做处理。向第二组注射人羊水，向第三组同时注射羊水和羊膜。在第一周结束时对24条肌腱进行组织病理学评分，在第二周结束时对24条肌腱进行组织病理学评分，在第三周结束时对24条肌腱进行生物力学评估。
仅在第一周时，第2组和第3组的组织病理学结果之间存在显著统计学差异。
人羊膜和羊水在跟腱断裂早期愈合过程中并无额外作用。
