Xu Jing, Su Hong-li, Wang Jun-hong, Zhang Chun-hong
Department of Endocrinology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. xujingj
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan;29(1):137-9.
To investigate the role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in type 2 diabetic nephropathy and provide new clues for prevention and treatment of type 2 diabetic nephropathy.
Flow cytometry was used to analyze the expression rate of CD4+CD25+Foxp3+ Treg cells in 60 patients with type 2 diabetes and 15 normal subjects.
No significant difference was found in the expression rate of CD4+CD25+Foxp3+ Treg cells between the control group and the type 2 diabetic patients. In the type 2 diabetic patients with microalbuminuria and macroalbuminuria, the expression of CD4+CD25+Foxp3+ Treg cells was significantly lowered in comparison with that in the control group (P<0.05), and patients with macroalbuminuria showed significantly lower expression of CD4+CD25+Foxp3+ Treg cells than the microalbuminuric patinets (P<0.05). Significant inverse correlations were noted between the disease course and the expression of CD4+CD25+Foxp3+ Treg cells and between the urinary albumin excretion rate (UAER) and the expression of CD4+CD25+Foxp3+ Treg cells.
CD4+CD25+Foxp3+ Treg cells may play a role in the occurrence and development of type 2 diabetic nephropathy.
探讨CD4+CD25+Foxp3+调节性T细胞（Treg）在2型糖尿病肾病中的作用，为2型糖尿病肾病的防治提供新线索。
采用流式细胞术分析60例2型糖尿病患者和15例正常对照者CD4+CD25+Foxp3+ Treg细胞的表达率。
对照组与2型糖尿病患者CD4+CD25+Foxp3+ Treg细胞表达率差异无统计学意义。2型糖尿病微量白蛋白尿和大量白蛋白尿患者CD4+CD25+Foxp3+ Treg细胞表达较对照组显著降低（P<0.05），大量白蛋白尿患者CD4+CD25+Foxp3+ Treg细胞表达低于微量白蛋白尿患者（P<0.05）。病程与CD4+CD25+Foxp3+ Treg细胞表达、尿白蛋白排泄率（UAER）与CD4+CD25+Foxp3+ Treg细胞表达均呈显著负相关。
CD4+CD25+Foxp3+ Treg细胞可能在2型糖尿病肾病的发生发展中起作用。
